Mastering IPAMORELIN Cycles: Ideal Doses, Scheduling, and Top Peptide Combinations
Sermorelin and ipamorelin are two popular growth hormone secretagogues that many athletes, bodybuilders, and anti-aging enthusiasts combine to stimulate the pituitary gland into producing more natural growth hormone (GH). The blend offers a synergistic effect: sermorelin, a synthetic analogue of growth hormone releasing hormone (GHRH), triggers the release of endogenous GH, while ipamorelin, a selective ghrelin receptor agonist, provides a sustained stimulation that is gentle on the body and tends to cause less side-effects such as water retention or increased appetite. When used together in a carefully timed cycle, this combination can enhance muscle growth, fat loss, recovery, and overall well-being.
Ipamorelin Cycle Guide: Optimal Dosage, Timing, and Best Peptide Stacks
The most common protocol for blending sermorelin with ipamorelin involves a split-dose strategy that targets both early morning and late evening peaks of natural GH secretion. A typical regimen looks like this:
Morning dose (6–7 AM): 10 µg of sermorelin mixed with 20 µg of ipamorelin in a single injection.
Evening dose (10–11 PM): 10 µg of sermorelin plus 30 µg of ipamorelin before bed.
This schedule aligns the peptide peaks with the body’s circadian rhythm, encouraging a natural surge of GH during sleep and supporting anabolic processes throughout the day. The total daily dose remains modest—around 40–50 µg of ipamorelin and 20 µg of sermorelin—minimizing the risk of overstimulation while still providing measurable benefits.
Stacking considerations
With Melatonin: Adding a low-dose melatonin (0.5–3 mg) at bedtime can improve sleep quality, which in turn amplifies GH release.
Sermorelin and ipamorelin are two popular growth hormone secretagogues that many athletes, bodybuilders, and anti-aging enthusiasts combine to stimulate the pituitary gland into producing more natural growth hormone (GH). The blend offers a synergistic effect: sermorelin, a synthetic analogue of growth hormone releasing hormone (GHRH), triggers the release of endogenous GH, while ipamorelin, a selective ghrelin receptor agonist, provides a sustained stimulation that is gentle on the body and tends to cause less side-effects such as water retention or increased appetite. When used together in a carefully timed cycle, this combination can enhance muscle growth, fat loss, recovery, and overall well-being.
Ipamorelin Cycle Guide: Optimal Dosage, Timing, and Best Peptide Stacks
The most common protocol for blending sermorelin with ipamorelin involves a split-dose strategy that targets both early morning and late evening peaks of natural GH secretion. A typical regimen looks like this:
Morning dose (6–7 AM): 10 µg of sermorelin mixed with 20 µg of ipamorelin in a single injection.
Evening dose (10–11 PM): 10 µg of sermorelin plus 30 µg of ipamorelin before bed.
This schedule aligns the peptide peaks with the body’s circadian rhythm, encouraging a natural surge of GH during sleep and supporting anabolic processes throughout the day. The total daily dose remains modest—around 40–50 µg of ipamorelin and 20 µg of sermorelin—minimizing the risk of overstimulation while still providing measurable benefits.
Stacking considerations
With Melatonin: Adding a low-dose melatonin (0.5–3 mg) at bedtime can improve sleep quality, which in turn amplifies GH release.